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Without adequate B12, DNA synthesis falters, producing enlarged, dysfunctional red blood cells characteristic of megaloblastic anemia

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They also suggest that the elevation of homocysteine may have multifactorial effects, interacting with both the vascular wall structure and the blood coagulation system, with different outcomes depending on the tissue and on the consequent degree of hyperhomocysteinemia

The absence of ANME archaea was initially surprising, as it implied low bioavailability of methane in Site 9.2

Rare side effects can include: Changes in blood pressure